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John Barrymore
John Barrymore became famous for playing sympathetic drunks on film, no great stretch for him given he was a fully-fledged, dedicated alcoholic off-camera all his life.
As a Shakespearian stage actor he was brilliant in his youth, able to memorize and deliver extraordinarily long speeches effortlessly and without a blemish. But as the years caught up with him, so did his drinking and it seriously damaged his brain and his ability to remember things.
On a cruise he once attempted to curb his alcoholism by locking himself in his cabin.
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But it was hopeless. He raided the bathroom and was soon downing mouthwash, perfume and Spirit of Camphor – anything that contained even a semblance of alcohol. As he literally staggered through the final years of his life he regularly arrived on-stage intoxicated.
In one memorable performance he halted mid-speech and relieved himself in a flower-pot at the front of the stage! In the end he could not remember the simples